Hirt Lab
Suitability of Aminolipin® as a fixative for histological and microscopic analysis
The fixation agent Aminolipin® was developed at the Institute of Clinical Anatomy and Cell Analysis as a substitute for the carcinogenic formaldehyde and is currently evaluated extensively for use in anatomical macroscopy. Works on efficacy, functionality and hazard potential for the user were funded by two BMBF programmes and by the German Social Accident Insurance (Deutsche Gesetzliche Unfallversicherung/DGUV). Extensive anatomical studies demonstrated the excellent fixation and preservation effectiveness of Aminolipin® for human whole-body preparations. Thanks to the newly discovered efficient inhibition of proteases relevant for autolysis, Aminolipin® has the potential to replace formaldehyde for the fixation and preservation of biological materials.
Contact
Prof. Dr Bernhard Hirt, MD
Director
Key Methods of the Lab
Molecular and cell-biological analysis, fixative chemicals and solutions, development of histological methods, Advanced Microscopy
The Aminolipin® Principle
Aminolipin® is a propylene diamine derivative containing a pyrrolidone ring and a carbon tail.
Aminolipin® is a fundamentally novel biocidal agent that is highly effective in inhibiting functional proteins.